Cytomegalovirus Vaccines
نویسندگان
چکیده
منابع مشابه
Cytomegalovirus Towne/Toledo Chimeric Vaccines
Thomas C. Heineman, Mark Schleiss, David I. Bernstein, Richard R. Spaete, Lihan Yan, Greg Duke, Mark Prichard, Zhaoti Wang, Qing Yan, Margaret A. Sharp, Nicola Klein, Ann M. Arvin, and George Kemble Division of Infectious Diseases and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri; Division of Pediatric Infectious Diseases, Children’s Hospital Medical Center, Univers...
متن کاملCytomegalovirus vaccines under clinical development
Congenital cytomegalovirus (CMV) infection is the most common infectious cause of disability in newborn infants. CMV also causes serious disease in solid organ (SOT) and haematopoietic stem cell transplant (HSCT) recipients. In otherwise healthy children and adults, primary CMV infection rarely causes illness. However, even asymptomatic CMV infections may predispose an individual towards an inc...
متن کاملChimpanzees Inoculated with Cytomegalovirus Contaminated Polio Vaccines may Explain
The genomic sequences of HIV-1 isolates are closely related to the sequences of simian immunodeficiency viruses of chimpanzees SIV (cpz) [1]. It is widely presumed, therefore, that a SIV (cpz)-derived virus can evolve into HIV. The time at which humans initially became infected with SIV (cpz) or with a SIV (cpz)-derived virus is less certain. Yet this is clearly relevant to the likely mode of v...
متن کاملA Phase 1 Study of 4 Live, Recombinant Human Cytomegalovirus Towne/Toledo Chimera Vaccines in Cytomegalovirus-Seronegative Men.
BACKGROUND Human cytomegalovirus (HCMV) infection causes disease in newborns and transplant recipients. A HCMV vaccine (Towne) protects transplant recipients. METHODS The genomes of Towne and the nonattenuated Toledo strain were recombined, yielding 4 Towne/Toledo chimera vaccines. Each of 36 HCMV-seronegative men received 1 subcutaneous dose of 10, 100, or 1000 plaque-forming units (PFU) i...
متن کاملDesign and Analysis of Rhesus Cytomegalovirus IL-10 Mutants as a Model for Novel Vaccines against Human Cytomegalovirus
BACKGROUND Human cytomegalovirus (HCMV) expresses a viral ortholog (CMVIL-10) of human cellular interleukin-10 (cIL-10). Despite only ∼26% amino acid sequence identity, CMVIL-10 exhibits comparable immunosuppressive activity with cIL-10, attenuates HCMV antiviral immune responses, and contributes to lifelong persistence within infected hosts. The low sequence identity between CMVIL-10 and cIL-1...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2013
ISSN: 1537-6591,1058-4838
DOI: 10.1093/cid/cit587